Captain Planet and the Planeteers

Captain Planet and the Planeteers was an American-Belgian-French animated program created by Ted Turner and Barbara Pyle. The series was produced by Turner Program Services and DIC Enterprises and broadcast on TBS from September 15, 1990, to December 5, 1992. The story centered around the Planeteers, five young adults who were given the powers of fire, water, earth, wind, and heart from Gaia, the Spirit of the Earth, fight villains who were polluting the Earth. When troubles got difficult, the Planeteers combine the five powers to summon Captain Planet.

Skumm Lord (Season 1, Episode 4)
Verminous Skumm, a mutant humanoid rat and one of the major villains of the series, creates a chemical disease called Rat Rot and contaminates several water supplies in Brazil with it. Anyone who drinks the contaminated water will turn into a mutant rat like himself and be under his control. The Planeteers manage to shut down one of Skumm's plants producing Rat Rot, but Wheeler, Linka, and Gi, in trying to shut down another of Skumm's plants, are exposed to Rat Rot and become mutant humanoids rats under the control of Skumm. Kwame and Ma-Ti, the remaining Planeteers, grab the others and head to the jungle to locate a plant capable for curing Rat Rot. The plant is in danger of being lost to cattle ranching, and only Ma-Ti's friend the Shaman knows where to find it. With the plant in hand, The Shaman cures the other Planeteers of Rat Rot and Captain Planet gathers the flowers and spread the cure to all of the affected people.